Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches

  title={Modelling the molecular mechanisms of synaptic plasticity using systems biology approaches},
  author={Jeanette Kotaleski and Kim T. Blackwell},
  journal={Nature Reviews Neuroscience},
Synaptic plasticity is thought to underlie learning and memory, but the complexity of the interactions between the ion channels, enzymes and genes that are involved in synaptic plasticity impedes a deep understanding of this phenomenon. Computer modelling has been used to investigate the information processing that is performed by the signalling pathways involved in synaptic plasticity in principal neurons of the hippocampus, striatum and cerebellum. In the past few years, new software… CONTINUE READING


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