Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties

@article{Dai2013ModellingTI,
  title={Modelling the integrated regulation role of β-adrenergic signaling and CaMKII in human myocyte electrophysiological properties},
  author={Ling Dai and Yunliang Zang and Dingchang Zheng and Ruyi Luo and Ling Xia},
  journal={Computing in Cardiology 2013},
  year={2013},
  pages={389-392}
}
Both ß-Adrenergic receptor (ß-AR) signaling pathway and Ca2+/Calmodulin-dependent protein kinase II (CaMKII) play important roles in regulating cardiac excitation-contraction coupling. However, the laboratory experiments cannot quantify these regulatory roles easily, computer models have been used as an alternative way. The aim of this study was to use computer models to preliminarily investigate the combined role of ß-AR and CaMKII in human cardiac myocyte properties With the hypothesis that… CONTINUE READING