Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens.

@article{Lloyd2009ModellingTH,
  title={Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens.},
  author={Christopher O Lloyd and David Lowe and Benjamin Edwards and Fraser Welsh and T Dilks and Colin Hardman and Thomas Vaughan},
  journal={Protein engineering, design & selection : PEDS},
  year={2009},
  volume={22 3},
  pages={159-68}
}
A large 1.29 x 10(11) antibody fragment library, based upon variable (V) genes isolated from human B-cells from 160 donors has been constructed and its performance measured against a panel of 28 different clinically relevant antigens. Over 5000 different target-specific antibodies were isolated to the 28 antigens with 3340 identified as modulating the biological function (e.g. antagonism, agonism) of the target antigen. This represents an average of approximately 120 different functionally… CONTINUE READING

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