Modelling the heart: insights, failures and progress.

  title={Modelling the heart: insights, failures and progress.},
  author={Denis Noble},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={24 12},
  • Denis Noble
  • Published 2002 in
    BioEssays : news and reviews in molecular…
Mathematical models of the heart have developed over a period of about 40 years. Cell types in all regions of the heart have been modelled and they are now being incorporated into anatomically detailed models of the whole organ. This combination is leading to the creation of the first 'virtual organ,' which is being used in drug discovery and testing, and in simulating the action of devices, such as cardiac defibrillators. Simulation is a necessary tool of analysis in attempting to understand… CONTINUE READING
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