Modelling the epidemiological impact of scaling up HIV testing and antiretroviral treatment in China.
@article{Zhang2012ModellingTE,
title={Modelling the epidemiological impact of scaling up HIV testing and antiretroviral treatment in China.},
author={Lei Zhang and Richard T Gray and David P. Wilson},
journal={Sexual health},
year={2012},
volume={9 3},
pages={
261-71
}
}BACKGROUND
The HIV epidemic in China has been increasing. In response, a 5-year action plan in China has prioritised the scale-up of HIV testing and treatment.
METHODS
We use a mathematical model to reproduce HIV epidemic trends in China and to forecast epidemic trends according to current conditions or increases in the rate of HIV testing or roll-out of antiretroviral therapy.
RESULTS
We show that the epidemic in China could be expected to experience a 2.5-fold expansion over the next 5…
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References
SHOWING 1-10 OF 100 REFERENCES
The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models.
- BiologyAIDS
- 2005
It is predicted that (over the next decade) in Africa, the impact of ART on reducing HIV transmission (and prevalence) is likely to be undetectable (unless accompanied by substantial changes in behavior), and large-scale surveillance for detecting transmitted resistance in Africa is unnecessary.
Predicting the epidemiological impact of antiretroviral allocation strategies in KwaZulu-Natal: The effect of the urban–rural divide
- MedicineProceedings of the National Academy of Sciences
- 2006
Predicting the epidemiological impact of drug allocation strategies (DAS) by using a spatially explicit model that links urban and rural epidemics, it is found that a Durban-only DAS would generate the lowest levels of transmitted resistance.
Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model
- MedicineThe Lancet
- 2009
Overview of the HIV/AIDS epidemic, scientific research and government responses in China
- MedicineAIDS
- 2007
The Chinese government has taken bold steps to scale-up HIV testing and counseling, offer free anti-retroviral treatment to AIDS patients, and expand primary prevention measures such as methadone maintenance and needle exchange programs for drug users and condom promotion for sex workers and men who have sex with men.
Epidemiology of HIV in China
- MedicineBMJ : British Medical Journal
- 2002
The first case of AIDS in China was diagnosed in 1985, heralding the HIV epidemic in mainland China. As of 30 September 2001 the Chinese Ministry of Health reported a total of 28 133 people infected…
The Chinese free antiretroviral treatment program: challenges and responses.
- MedicineAIDS
- 2007
The Free ART Program has made considerable progress in providing the necessary care and treatment for HIV-infected people in China and has strong government support for continued improvement and expansion.
Estimating the number of people at risk for and living with HIV in China in 2005: methods and results
- Medicine, Political ScienceSexually Transmitted Infections
- 2006
The number of people exposed to HIV in China, the number living with HIV, and the number of new HIV infections and deaths in 2005 are used to make new estimates based on a much wider range of surveillance data as well as mass screening of former plasma donors.
Risk of HIV/AIDS in China: subpopulations of special importance
- MedicineSexually Transmitted Infections
- 2005
Though commercial sex workers have contributed to a small proportion of the reported epidemic thus far, flourishing commercial sex is of growing concern and may have a bridging role in transmitting HIV from core groups to the general population.
HIV/AIDS epidemiology and prevention in China.
- Medicine, Political ScienceChinese medical journal
- 2008
The overall HIV/AIDS epidemic is at a low level (0.05%) and concentrated in several at risk populations, however, the data show that new cases of HIV infection are growing every year and spreading from atrisk populations to the general population.
Importance of promoting HIV testing for preventing secondary transmissions: modelling the Australian HIV epidemic among men who have sex with men.
- MedicineSexual health
- 2009
Promoting increases in the coverage and frequency of testing for HIV could be a highly-effective public health intervention, but the population-level impact of interventions based on promoting early treatment of patients diagnosed in primary HIV infection (PHI) is likely to be small.