Modelling the enhancement of fractionated radiotherapy by gene transfer to sensitize tumour cells to radiation.

@article{Wheldon1998ModellingTE,
  title={Modelling the enhancement of fractionated radiotherapy by gene transfer to sensitize tumour cells to radiation.},
  author={T. E. Wheldon and Robert J. Mairs and R. P. Rampling and Anne Marie Barrett},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1998},
  volume={48 1},
  pages={
          5-13
        }
}
BACKGROUND AND PURPOSE Several strategies now exist for the use of gene transfer methodologies to sensitize tumour cells to radiation. These include the transfection of genes synthesizing cytokines, p53 gene replacement and methods based on the use of HSV-tk and gancyclovir. Very recently, the sequencing of radioprotector or repair genes, such as ATM, Ku80 and XRCC2, has made it possible to consider the design of gene transfer strategies resulting in protector gene knock-out. Selectivity of… CONTINUE READING

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