Modelling the controls of the eukaryotic cell cycle.

  title={Modelling the controls of the eukaryotic cell cycle.},
  author={B{\'e}la Nov{\'a}k and John J. Tyson},
  journal={Biochemical Society transactions},
  volume={31 Pt 6},
The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive… CONTINUE READING