Modelling the Evolution and Spread of HIV Immune Escape Mutants

  title={Modelling the Evolution and Spread of HIV Immune Escape Mutants},
  author={Helen R. Fryer and John A. Frater and Anna Krystyna Duda and Mick G. Roberts and Rodney E. Phillips and Angela R. McLean},
  booktitle={PLoS pathogens},
During infection with human immunodeficiency virus (HIV), immune pressure from cytotoxic T-lymphocytes (CTLs) selects for viral mutants that confer escape from CTL recognition. These escape variants can be transmitted between individuals where, depending upon their cost to viral fitness and the CTL responses made by the recipient, they may revert. The rates of within-host evolution and their concordant impact upon the rate of spread of escape mutants at the population level are uncertain. Here… CONTINUE READING
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