• Chemistry
  • Published 2011

Modelling of tolerance and rebound in normal and diseased rats

@inproceedings{Ahlstrm2011ModellingOT,
  title={Modelling of tolerance and rebound in normal and diseased rats},
  author={Christine Ahlstr{\"o}m},
  year={2011}
}
The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. In this thesis nicotinic acid (NiAc)-induced changes in non-esterified fatty acids (NEFA) were used as a tool to investigate key determinants of tolerance and rebound in normal Sprague Dawley and in obese Zucker rats, a disease model of… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Dose-response-time data analysis

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Challenging the dose‐response‐time data approach: Analysis of a complex system

VIEW 1 EXCERPT
CITES BACKGROUND

Dose-response-time modelling: Second-generation turnover model with integral feedback control.

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 162 REFERENCES

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro

  • L. A. Carlson
  • Acta. Med. Scand
  • 1963
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A nonlinear feedback model capturing different patterns of tolerance and rebound.

  • Johan Gabrielsson, L. A. Peletier
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2007
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Efficacy and safety of an extended-release niacin (Niaspan): a long-term study.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL