Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy.

@article{Chen2003ModellingOS,
  title={Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy.},
  author={C. Y. Chen and Yolande Cordeaux and Stephen J Hill and John R. King},
  journal={Bulletin of mathematical biology},
  year={2003},
  volume={65 5},
  pages={933-58}
}
A mathematical model is constructed to study promiscuous coupling of receptors to G-proteins and to simulate events leading to the activation of multiple effector pathways within a cell. The model is directed at a better understanding of the factors that determine the efficacy and potency of a drug. Assuming that the receptors can exist in multiple conformational states, and allowing for agonist specific conformation, a system of ordinary differential equations is constructed and subsequently… CONTINUE READING

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