Modelling of location- and time-dependent deformation of chondrocytes during cartilage loading.

@article{Wu1999ModellingOL,
  title={Modelling of location- and time-dependent deformation of chondrocytes during cartilage loading.},
  author={Jian zhong Wu and Walter Herzog and Marcelo Epstein},
  journal={Journal of biomechanics},
  year={1999},
  volume={32 6},
  pages={563-72}
}
Experimental evidence suggests that the biosynthetic activity of chondrocytes is regulated primarily by the mechanical environment. In order to study the mechanisms underlying remodeling, adaptation, and degeneration of articular cartilage in a joint subjected to changing loads, it is important to know the time-dependent fluid pressure and stress-strain state in chondrocytes. The purpose of the present study was to develop a theoretical model to simulate the mechanical behaviour of articular… CONTINUE READING