Modelling of age-related bone loss using cross-sectional data

@article{Malkin2002ModellingOA,
  title={Modelling of age-related bone loss using cross-sectional data},
  author={I. Malkin and D. Karasik and G. Livshits and E. Kobyliansky},
  journal={Annals of Human Biology},
  year={2002},
  volume={29},
  pages={256 - 270}
}
Background : Current applications of bone mineral density (BMD) data in age studies are not free of certain drawbacks. Since it is well established that age-related patterns of BMD changes involve three distinct periods (bone acquisition in youth, stabilization at maturity, and decrease with ageing), adjusting for age via an inappropriate mathematical function may lead to inconsistencies and wrong conclusions. Hypothesis : The piecewise model, which encompasses the above three periods, will… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Population biology of human aging: methods of assessment and sex variation.
TLDR
The distributions of the observed biological age estimates adjusted on the expected biological age values reveal no differences between men and women in any of the studied samples or in the total population. Expand
Population biology of human aging: segregation analysis of bone age characteristics.
TLDR
The results of the segregation analysis performed on BMD clearly indicate major gene effects on B MD variation, and the Mendelian transmissibility hypothesis with two codominant alleles was chosen as the best-fitting and most parsimonious model. Expand
Classification of Osteoporosis Based on Bone Mineral Densities
  • Y. Lu, H. Genant, +4 authors S. Cummings
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2001
TLDR
It is concluded that standardization of normative data, perhaps referenced to an older population, may be necessary when applying T scores as diagnostic criteria in patient management and a risk‐based osteoporosis classification does not depend on the manufacturers' reference data and may be more consistent and efficient for patient diagnosis. Expand
Variation in bone mineral density in adults in Poland: age and sex differences.
TLDR
By the age of 60 years mean trabecular and cortical densities in males have decreased to levels almost equivalent to females of equal age, a distinctly different pattern was found among males, with bone densities reaching peak values, markedly higher than those in females, in the third decade of life. Expand
Updated Data on Proximal Femur Bone Mineral Levels of US Adults
TLDR
The updated data on BMD for the total femur ROI of NHW have been selected as the reference database for femur standardization efforts by the International Committee on Standards in Bone Measurements. Expand
Comparisons of Noninvasive Bone Mineral Measurements in Assessing Age‐Related Loss, Fracture Discrimination, and Diagnostic Classification
  • S. Grampp, H. Genant, +6 authors M. Chávez
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1997
The purpose of this study was to examine the commonly available methods of noninvasively assessing bone mineral status across three defined female populations to examine their interrelationships,Expand
Age-related changes of whole skeleton and body composition in healthy men
TLDR
It is confirmed that in males the principal determinant of total body bone density is fat-free mass, andLean mass declined in a uniform way from the first to the last decades, but there were no correlations with the fat mass. Expand
Population biology of human aging: ethnic and climatic variation of bone age scores.
TLDR
Hand radiograms for osseographic assessment of bone-aging status were taken from more than 7500 individuals living in 32 different geographic localities and belonging to 20 ethnic groups to determine whether population differences inBone-aging estimates were related to linguistic, ethnic, or genetic differences among the samples. Expand
Bone ageing: genetics versus environment.
TLDR
The study of cortical index (CI) provided evidence that a single potential major gene controls not only the baseline trait level, but also the age at onset of the involutive bone changes, and the rate of the CI change with age. Expand
Age and Sex Differences in the Bone Mineral Density of the Distal Forearm Based on Health Check-up Data of 6343 Japanese
TLDR
No evidence of racial differences in BMD as an explanation for the lower incidence of osteoporotic fractures in Japan is found and rates of gain and loss of forearm BMD differ between the sexes. Expand
...
1
2
3
4
5
...