Modelling of Ca2+-activated chloride current in tracheal smooth muscle cells.

@article{Roux2001ModellingOC,
  title={Modelling of Ca2+-activated chloride current in tracheal smooth muscle cells.},
  author={Etienne Roux and P. J. Noble and J M Hyvelin and Douglas Noble},
  journal={Acta biotheoretica},
  year={2001},
  volume={49 4},
  pages={291-300}
}
Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl- current (I(ClCa)) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model I(ClCa) in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple… CONTINUE READING

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