Modelling early responses to neurodegenerative mutations in mice.

  title={Modelling early responses to neurodegenerative mutations in mice.},
  author={Jonathan Gilley and R{\'o}bert Adalbert and Michael P. Coleman},
  journal={Biochemical Society transactions},
  volume={39 4},
Considering the many differences between mice and humans, it is perhaps surprising how well mice model late-onset human neurodegenerative disease. Models of Alzheimer's disease, frontotemporal dementia, Parkinson's disease and Huntington's disease show some striking similarities to the corresponding human pathologies in terms of axonal transport disruption, protein aggregation, synapse loss and some behavioural phenotypes. However, there are also major differences. To extrapolate from mouse… CONTINUE READING
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A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene

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