Modelling base pair opening: the role of helical twist☆

@inproceedings{Bernet1997ModellingBP,
  title={Modelling base pair opening: the role of helical twist☆},
  author={Juliette Bernet and Krystyna Zakrzewska and Richard Lavery},
  year={1997}
}
Abstract Molecular modelling with the JUMNA program has been used to study the conformational and energetic aspects of base pair opening within a B-DNA double helix. Using new geometrical restraints, it has been possible to map base opening into the minor and major grooves of the double helix, without fixing an axis of rotation or the plane in which the base moves. The results show notably that minor groove opening is favoured by locally unwound DNA. Although the modelling is carried out with a… CONTINUE READING

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