Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin.

@article{Carraro2007ModellingAS,
  title={Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin.},
  author={R. Carraro and J. Bua and A. Ru{\'i}z and M. Paulino},
  journal={Journal of molecular graphics & modelling},
  year={2007},
  volume={26 1},
  pages={
          48-61
        }
}
  • R. Carraro, J. Bua, +1 author M. Paulino
  • Published 2007
  • Chemistry, Medicine
  • Journal of molecular graphics & modelling
    • Cyclophilins (CyPs) are enzymes involved in protein folding, catalyzing the isomerisation of peptidyl prolyl bonds in proteins and peptides between the cis- and trans-conformations. They are also the major cellular target for the immunosuppressive drug Cyclosporin A (CsA). In Trypanosoma cruzi, the most abundantly expressed CyP is an isoform of 19 kDa, TcCyP19, in which the enzymatic activity is inhibited by CsA. Among a reported set of CsA analogues, two non-immunosuppressive compounds, H-7-94… CONTINUE READING
    View on PubMed
    doi.org
    6 Citations
    Background Citations
    3
    Results Citations
    1

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    6 Citations
    Citation Type

    Citation Type

    Analysis of cyclosporin A and a set of analogs as inhibitors of a T. cruzi cyclophilin by docking and molecular dynamics
    • 4
    A Functional Analysis of the Cyclophilin Repertoire in the Protozoan Parasite Trypanosoma Cruzi
    • 3
    • PDF
    Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.
    • 8
    • PDF
    Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.
    • 15
    • PDF
    Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth.
    Mechanism of Trypanosoma cruzi death induced by Cratylia mollis seed lectin
    • 32

    References

    SHOWING 1-10 OF 28 REFERENCES
    Characterisation of a cyclophilin isoform in Trypanosoma cruzi.
    • 18
    • PDF
    Three‐dimensional structure and actions of immunosuppressants and their immunophilins
    • 68
    In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi.
    • 27
    Structures of immunophilins and their ligand complexes.
    • 104
    Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue.
    • 138
    Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
    • 934
    Modelling a 3D structure for EgDf1 from shape Echinococcus granulosus: putative epitopes, phosphorylation motifs and ligand
    • 10
    The antiparasite effects of cyclosporin A: possible drug targets and clinical applications.
    • 46
    Analysis of the Trypanosoma cruzi cyclophilin gene family and identification of Cyclosporin A binding proteins.
    • 21
    The mechanism of action of cyclosporin A and FK506.
    • 1,060