Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin.

  title={Modelling and study of cyclosporin A and related compounds in complexes with a Trypanosoma cruzi cyclophilin.},
  author={R. Carraro and J. Bua and A. Ru{\'i}z and M. Paulino},
  journal={Journal of molecular graphics & modelling},
  volume={26 1},
  • R. Carraro, J. Bua, +1 author M. Paulino
  • Published 2007
  • Chemistry, Medicine
  • Journal of molecular graphics & modelling
  • Cyclophilins (CyPs) are enzymes involved in protein folding, catalyzing the isomerisation of peptidyl prolyl bonds in proteins and peptides between the cis- and trans-conformations. They are also the major cellular target for the immunosuppressive drug Cyclosporin A (CsA). In Trypanosoma cruzi, the most abundantly expressed CyP is an isoform of 19 kDa, TcCyP19, in which the enzymatic activity is inhibited by CsA. Among a reported set of CsA analogues, two non-immunosuppressive compounds, H-7-94… CONTINUE READING
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