Modelling and advanced understanding of unsteady-state gas transfer in shaking bioreactors.

@article{Amoabediny2007ModellingAA,
  title={Modelling and advanced understanding of unsteady-state gas transfer in shaking bioreactors.},
  author={Ghassem Amoabediny and Jochen B{\"u}chs},
  journal={Biotechnology and applied biochemistry},
  year={2007},
  volume={46 Pt 1},
  pages={57-67}
}
In shaken bioreactors equipped with a sterile closure (e.g. a cotton plug), a realistic understanding and estimation of gas transfer is advantageous to avoid oxygen limitation or carbon dioxide inhibition of a microbial culture. Therefore, in the present study, an unsteady-state gas-transfer model for shake flasks was developed and experimentally investigated for a wide range of gas-transfer resistances (k(plug)). The introduced approach is based on the model of Henzler and co-workers [Henzler… CONTINUE READING
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