Modelling Wolbachia infection in a sex-structured mosquito population carrying West Nile virus

@article{Farkas2017ModellingWI,
  title={Modelling Wolbachia infection in a sex-structured mosquito population carrying West Nile virus},
  author={Jozsef Z. Farkas and Stephen A. Gourley and Rongsong Liu and Abdul-Aziz Yakubu},
  journal={Journal of Mathematical Biology},
  year={2017},
  volume={75},
  pages={621 - 647}
}
Wolbachia is possibly the most studied reproductive parasite of arthropod species. It appears to be a promising candidate for biocontrol of some mosquito borne diseases. We begin by developing a sex-structured model for a Wolbachia infected mosquito population. Our model incorporates the key effects of Wolbachia infection including cytoplasmic incompatibility and male killing. We also allow the possibility of reduced reproductive output, incomplete maternal transmission, and different mortality… 
View on Springer
europepmc.org
26 Citations
Background Citations
9
Methods Citations
3
Results Citations
1

26 Citations

Citation Type

Citation Type

Wolbachia infection dynamics in mosquito population with the CI effect suffering by uninfected ova produced by infected females
TLDR
A stage-structure model to investigate the effective releasing strategies for Wolbachia-infected mosquitoes is presented and it is suggested that ignoring the CI effect suffering by uninfected ova produced by infected females may result in the overestimation of the threshold infection level for the Wolbachian invasion.
Optimal control approach for establishing wMelPop Wolbachia infection among wild Aedes aegypti populations
TLDR
An explicit sex-structured population model is proposed that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately infected with wMelPop strain of Wolbachia in the same locality to find a tradeoff between reaching the population replacement in minimum time and with minimum cost of the control effort.
A sex-structured model with birth pulse and release strategy for the spread of Wolbachia in mosquito population.
Monotonicity properties arising in a simple model of Wolbachia invasion for wild mosquito populations.
TLDR
In this paper, it is proved the existence of an invariant threshold manifold that allows for practical recommendations for performing single and periodic releases of Wolbachia-carrying mosquitoes, seeking the eventual elimination of wild insects that are capable of transmitting infections to humans.
A simplified monotone model of Wolbachia invasion encompassing Aedes aegypti mosquitoes
TLDR
This model not only facilitates better visualization of the Wolbachia invasion dynamics thanks to its bidimensionality, but it also possesses the noticeable property of monotonicity and exhibits the saddle‐point behavior.
Aedes aegypti and Wolbachia interaction: population persistence in an environment changing
TLDR
A mathematical model is proposed to assess the factibility of dengue control transmission using a transinfection of A. aegypti with a Wolbachia strain and predicts that mosquito population extinction can occur in a region of the parameter space where the reproductive number of the wild population is bigger than one and migration of mosquitoes from surrounding areas is not allowed.
Modeling the dynamics ofWolbachia-infected and uninfectedAedes aegypti populations by delay differential equations
TLDR
It is shown that the increase of the delay can promote, through Hopf bifurcation, stability switch towards instability for the nonzero equilibriums, and overall, when the delay increases and crosses predetermined thresholds, the populations go to extinction.
Wolbachia-based biocontrol for dengue reduction using dynamic optimization approach
Modeling and control of mosquito-borne diseases with Wolbachia and insecticides.
Models to assess the effects of non-identical sex ratio augmentations of Wolbachia-carrying mosquitoes on the control of dengue disease.
...
...

References

SHOWING 1-10 OF 65 REFERENCES
Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases
TLDR
It is demonstrated that male-biased release of Wolbachia-infected mosquitoes can cause substantial transmission reductions without transiently increasing disease risk and that female-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations.
Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission
TLDR
This work describes how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster, successfully invaded two natural A. aagypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A.A. ae Egyptian adults.
Wolbachia Enhances West Nile Virus (WNV) Infection in the Mosquito Culex tarsalis
TLDR
This is the first observation of Wolbachia-induced enhancement of a human pathogen in mosquitoes, suggesting that caution should be applied before releasing Wol Bachia-infected insects as part of a vector-borne disease control program.
Modelling the Use of Wolbachia to Control Dengue Fever Transmission
TLDR
It is shown that Wolbachia has excellent potential for dengue control in areas where R0 is not too large, and unless control measures to reduce R0 by reducing mosquito populations are also put in place, it may be worth the extra effort in such cases to introduce Wolbachian strains that eliminate denge transmission completely.
Effect of Wolbachia on Replication of West Nile Virus in a Mosquito Cell Line and Adult Mosquitoes
TLDR
The results suggest that despite the enhancement of viral genomic RNA replication in the Wolbachia-infected cell line the production of secreted virus was significantly inhibited, the antiviral effect in intrathoracically infected mosquitoes depends on the strain of Wol Bachia, and replication of the virus in orally fed mosquitoes was completely inhibited in wMelPop strain of Wbachia.
Infection dynamics of different Wolbachia-types within one host population.
Impact of population age structure on Wolbachia transgene driver efficacy: ecologically complex factors and release of genetically modified mosquitoes.
Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
TLDR
It is shown that stable introduction of the wMel strain of Drosophila melanogaster into Aedes albopictus, a vector of d Dengue and other arboviruses, abolished the transmission capacity of dengue virus-challenged mosquitoes.
The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
TLDR
The successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion is described.
Population Dynamic Models of the Spread of Wolbachia
TLDR
This work derives a new expression for the threshold frequency that extends existing theory to incorporate important details of the insect’s life history and shows how the type of immigration and the temporal dynamics of the host population can strongly affect the spread of Wolbachia.
...
...