Modelling Linkage Disequilibrium, And Identifying Recombination Hotspots Using SNP Data


We introduce a new statistical model for patterns of Linkage Disequilibrium (LD) among multiple SNPs in a population sample. The model overcomes limitations of existing approaches to understanding, summarizing, and interpreting LD by (i) relating patterns of LD directly to the underlying recombination process; (ii) considering all loci simultaneously… (More)


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