Modeling within-host evolution of HIV: mutation, competition and strain replacement.

@article{Ball2007ModelingWE,
  title={Modeling within-host evolution of HIV: mutation, competition and strain replacement.},
  author={Colleen L. Ball and Michael A. Gilchrist and Daniel Coombs},
  journal={Bulletin of mathematical biology},
  year={2007},
  volume={69 7},
  pages={2361-85}
}
Virus evolution during infection of a single individual is a well-known feature of disease progression in chronic viral diseases. However, the simplest models of virus competition for host resources show the existence of a single dominant strain that grows most rapidly during the initial period of infection and competitively excludes all other virus strains. Here, we examine the dynamics of strain replacement in a simple model that includes a convex trade-off between rapid virus reproduction… CONTINUE READING
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Virus Dynamics, 1st edn

  • M. Nowak, R. May
  • 2000
Highly Influential
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