Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility.

@article{Rong2007ModelingWH,
  title={Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility.},
  author={Libin Rong and Michael A. Gilchrist and Zhilan Feng and Alan S. Perelson},
  journal={Journal of theoretical biology},
  year={2007},
  volume={247 4},
  pages={804-18}
}
There are many biological steps between viral infection of CD4(+) T cells and the production of HIV-1 virions. Here we incorporate an eclipse phase, representing the stage in which infected T cells have not started to produce new virus, into a simple HIV-1 model. Model calculations suggest that the quicker infected T cells progress from the eclipse stage to the productively infected stage, the more likely that a viral strain will persist. Long-term treatment effectiveness of antiretroviral… CONTINUE READING

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