Modeling threshold phenomena, metabolic pathways switches and signals in chemostat-cultivated cells: the Crabtree effect in Saccharomyces cerevisiae.


The long-term Crabtree effect in Saccharomyces cerevisiae cultivated in aerobic chemostat at steady state has been studied for three different substrate concentrations in the feed of the bioreactor (data: J. Gen. Microbiol., 129 (1983) 653). We have shown that a model using two ways of transport/metabolization (T/M) of hyperbolic form, with high and low… (More)


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