Modeling three-dimensional protein structures for amino acid sequences of the CASP3 experiment using sequence-derived predictions.

@article{Fischer1999ModelingTP,
  title={Modeling three-dimensional protein structures for amino acid sequences of the CASP3 experiment using sequence-derived predictions.},
  author={Daniel Fischer},
  journal={Proteins},
  year={1999},
  volume={Suppl 3},
  pages={61-5}
}
Homology or comparative modeling is aimed at modeling the three-dimensional structure of a target sequence of unknown structure using the framework of an already known fold. Traditionally, homology modeling has been applied to targets with clear sequence similarity to proteins of known structure. Because methods to identify increasingly distant relationships have been developed, homology models can now be built for a wider range of targets. The first challenge in homology modeling is to obtain… CONTINUE READING