Modeling therapy resistance in genetically engineered mouse cancer models.

@article{Rottenberg2008ModelingTR,
  title={Modeling therapy resistance in genetically engineered mouse cancer models.},
  author={Sven Rottenberg and Jos Jonkers},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2008},
  volume={11 1-2},
  pages={51-60}
}
Resistance to anti-cancer drugs is a major obstacle in successful treatment of cancer. Multidrug resistance is not only observed with clinically established chemotherapeutics, but also with novel targeted therapies. Although a range of drug resistance mechanisms have been identified up till now, for most drugs it is still controversial which mechanisms are responsible for resistance and therapy failure in patients. Hence, the development of strategies to circumvent drug resistance is often… CONTINUE READING

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