Modeling the time-course of Alzheimer dementia.

  title={Modeling the time-course of Alzheimer dementia.},
  author={John Wesson Ashford and Frederick A. Schmitt},
  journal={Current psychiatry reports},
  volume={3 1},
Alzheimer's disease (AD) progresses from a preclinical period, through a middle phase of cognitive deterioration, to a late, profound state. The temporal progression of disability can be modeled with a horologic (time-based) function using "time-index" (TI) intervals (day- or year-units) to quantify an individual's disability across multiple cognitive and functional domains relative to a reference AD population. Clinicians and researchers can use TI quantification to assess dementia severity… CONTINUE READING

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  • 2000

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