Modeling the role of p53 pulses in DNA damage- induced cell death decision

@article{Sun2008ModelingTR,
  title={Modeling the role of p53 pulses in DNA damage- induced cell death decision},
  author={Tingzhe Sun and Chun Chen and Yuanyuan Wu and Shuai Zhang and Jun Cui and Pingping Shen},
  journal={BMC Bioinformatics},
  year={2008},
  volume={10},
  pages={190 - 190}
}
The tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear. To address these questions we presented an integrated model in which Ataxia-Telangiectasia Mutated (ATM) activation and p53 oscillation were incorporated with downstream apoptotic events, particularly the interplays between Bcl-2 family proteins. We first reproduced… CONTINUE READING