Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects.

@article{Buuse2010ModelingTP,
  title={Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects.},
  author={Maarten van den Buuse},
  journal={Schizophrenia bulletin},
  year={2010},
  volume={36 2},
  pages={246-70}
}
In recent years, there have been huge advances in the use of genetically modified mice to study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid progress in our understanding of the role of several proposed gene mechanisms in schizophrenia, and yet this research has also revealed how much still remains unresolved. Behavioral studies in genetically modified mice are reviewed with special emphasis on modeling psychotic-like behavior. I will particularly focus on… CONTINUE READING

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Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 18 Excerpts
Highly Influenced

Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 17 Excerpts
Highly Influenced

Neuregulin 1 and susceptibility to schizophrenia.

American journal of human genetics • 2002
View 6 Excerpts
Highly Influenced

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