Modeling the mammalian locomotor CPG: insights from mistakes and perturbations.

  title={Modeling the mammalian locomotor CPG: insights from mistakes and perturbations.},
  author={David A McCrea and Ilya A. Rybak},
  journal={Progress in brain research},
A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-center rhythm generator (RG) and pattern formation (PF) networks is reviewed. The model consists of interacting populations of interneurons and motoneurons described in the Hodgkin-Huxley style. Locomotor rhythm generation is based on a combination of intrinsic (persistent sodium current dependent) properties of excitatory RG neurons and reciprocal inhibition… CONTINUE READING
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