Modeling the kinetics of digoxin absorption: enhancement by P-glycoprotein inhibition.

Abstract

An increase in the area under the curve (AUC) after oral digoxin due to coadministration of drugs known as P-glycoprotein (P-gp) inhibitors has been reported in several studies, but there is very little information on the rate of absorption after P-gp inhibition. Based on an inverse Gaussian density absorption model and using a population approach, the… (More)
DOI: 10.1177/0091270010396711

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