Modeling the interactions of particulates with epithelial lining fluid antioxidants.

@article{Zieliski1999ModelingTI,
  title={Modeling the interactions of particulates with epithelial lining fluid antioxidants.},
  author={Henryk Zieliński and Ian S. Mudway and Kelly A B{\'e}rub{\'e} and Samantha Murphy and Roy J. Richards and F. J. Kelly},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={277 4},
  pages={L719-L726}
}
Oxidative stress may be a fundamental mode of injury associated with inspired particles. To examine this, we determined the ability of three carbon black particles (CBPs; M120, M880, and R250) and two forms of silicon dioxide, amorphous (Cabosil) and crystalline (DQ12) quartz, to deplete epithelium lining fluid antioxidant defenses. Single and composite antioxidant solutions of uric acid, ascorbic acid (AA), and reduced glutathione (GSH) were examined in the presence of particle concentrations… CONTINUE READING