Modeling the interactions of ozone with pulmonary epithelial lining fluid antioxidants.

@article{Mudway1998ModelingTI,
  title={Modeling the interactions of ozone with pulmonary epithelial lining fluid antioxidants.},
  author={Ian S. Mudway and F. J. Kelly},
  journal={Toxicology and applied pharmacology},
  year={1998},
  volume={148 1},
  pages={91-100}
}
Water soluble antioxidant--ascorbate (AA), urate (UA), and reduced glutathione (GSH)--consumption by ozone (O3) was investigated in a range of pulmonary epithelial lining fluid (ELF) models. Antioxidants were exposed individually and as a composite mixture, with and without human albumin to a range of ambient O3 concentrations: 0-1500 ppb using a continually mixed, interfacial exposure setup. We observed the following: (1) UA constituted the most o3-reactive substrate in each of the models… CONTINUE READING

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