Modeling the interaction of fipronil-related non-competitive antagonists with the GABA beta3-receptor.

@article{Ci2007ModelingTI,
  title={Modeling the interaction of fipronil-related non-competitive antagonists with the GABA beta3-receptor.},
  author={Suqin Ci and Tianrui Ren and Zhiguo Su},
  journal={Journal of molecular modeling},
  year={2007},
  volume={13 3},
  pages={457-64}
}
A three-dimensional model of the beta3-homopentamer of the gamma-aminobutyric acid (GABA) receptor/chloride ionophore complex was developed by homology modeling using the cyro-electron microscopy structure of nicotinic acetylcholine as a template. Interactions between the beta3-homopentamer and two classes of fipronil-related non-competitive antagonists were investigated using docking studies. The phenyl groups of these compounds were stabilized by strong hydrophobic and hydrophilic… CONTINUE READING

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