Modeling the impact of spatial oxygen heterogeneity on radiolytic oxygen depletion during FLASH radiotherapy

@article{Taylor2022ModelingTI,
  title={Modeling the impact of spatial oxygen heterogeneity on radiolytic oxygen depletion during FLASH radiotherapy},
  author={Edward Taylor and Richard Peter Hill and Daniel L{\'e}tourneau},
  journal={Physics in Medicine \& Biology},
  year={2022},
  volume={67}
}
Purpose. It has been postulated that the delivery of radiotherapy at ultra-high dose rates (‘FLASH’) reduces normal tissue toxicities by depleting them of oxygen. The fraction of normal tissue and cancer cells surviving radiotherapy depends on dose and oxygen levels in an exponential manner and even a very small fraction of tissue at low oxygen levels can determine radiotherapy response. To quantify the differential impact of FLASH radiotherapy on normal and tumour tissues, the spatial… 

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