Modeling the hypothalamus-pituitary-adrenal axis: A review and extension.

@article{Hosseinichimeh2015ModelingTH,
  title={Modeling the hypothalamus-pituitary-adrenal axis: A review and extension.},
  author={Niyousha Hosseinichimeh and Hazhir Rahmandad and Andrea K Wittenborn},
  journal={Mathematical biosciences},
  year={2015},
  volume={268},
  pages={52-65}
}
Multiple models of the hypothalamus-pituitary-adrenal (HPA) axis have been developed to characterize the oscillations seen in the hormone concentrations and to examine HPA axis dysfunction. We reviewed the existing models, then replicated and compared five of them by finding their correspondence to a dataset consisting of ACTH and cortisol concentrations of… CONTINUE READING