Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches

@inproceedings{Abarrategi2018ModelingTH,
  title={Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches},
  author={Ander Abarrategi and Salman Aziz Mian and Diana Passaro and Kevin Rouault-Pierre and William Grey and Dominique Bonnet},
  booktitle={The Journal of experimental medicine},
  year={2018}
}
Xenotransplantation of patient-derived samples in mouse models has been instrumental in depicting the role of hematopoietic stem and progenitor cells in the establishment as well as progression of hematological malignancies. The foundations for this field of research have been based on the development of immunodeficient mouse models, which provide normal and malignant human hematopoietic cells with a supportive microenvironment. Immunosuppressed and genetically modified mice expressing human… CONTINUE READING
87
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Murine Models of Acute Myeloid Leukaemia

  • International journal of molecular sciences
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Role of the Extracellular Matrix in Stem Cell Maintenance

Ana Pardo-Saganta, Isabel A. Calvo, Borja Saez, Felipe Prosper
  • Current Stem Cell Reports
  • 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 205 REFERENCES

Implantable microenvironments to attract hematopoietic stem/cancer cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Tsvee Lapidot, Christian Sirard, +7 authors John E. Dick
  • Nature
  • 1994
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL