Modeling the evolution of the human mitochondrial genome.

  title={Modeling the evolution of the human mitochondrial genome.},
  author={R C Lundstrom and Simon Tavar{\'e} and R H Ward},
  journal={Mathematical biosciences},
  volume={112 2},
Mitochondrial DNA data have been used extensively to study evolution and early human origins. These applications require estimates of the rate at which nucleotide substitutions occur in the DNA sequence. We consider the problem of estimating substitution rates in the presence of site-to-site rate variation. A coalescent model is presented that allows for different substitution rates for purines and pyrimidines, as well as more detailed models that allow fast and slow rates within each of the… CONTINUE READING

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