Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair.

@article{Dallon2001ModelingTE,
  title={Modeling the effects of transforming growth factor-beta on extracellular matrix alignment in dermal wound repair.},
  author={John C. Dallon and Jonathan A. Sherratt and Philip K. Maini},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2001},
  volume={9 4},
  pages={278-86}
}
We present a novel mathematical model for collagen deposition and alignment during dermal wound healing, focusing on the regulatory effects of transforming growth factor-beta (TGFbeta.) Our work extends a previously developed model which considers the interactions between fibroblasts and an extracellular matrix composed of collagen and a fibrin based blood clot, by allowing fibroblasts to orient the collagen matrix, and produce and degrade the extracellular matrix, while the matrix directs the… CONTINUE READING
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