Modeling the effect of acylated homoserine lactone antagonists in Pseudomonas aeruginosa.

@article{Fagerlind2005ModelingTE,
  title={Modeling the effect of acylated homoserine lactone antagonists in Pseudomonas aeruginosa.},
  author={Magnus G Fagerlind and Patric Nilsson and Mikael Harl{\'e}n and Sandra Karlsson and Scott A Rice and Staffan J. Kjelleberg},
  journal={Bio Systems},
  year={2005},
  volume={80 2},
  pages={201-13}
}
Pseudomonas aeruginosa is a gram-negative bacterium that causes serious illnesses, particularly in immunocompromised individuals, often with a fatal outcome. The finding that the acylated homoserine lactone quorum sensing (QS) system controls the production of virulence factors in P. aeruginosa makes this system a possible target for antimicrobial therapy. It has been suggested that an N-(3-oxododecanoyl)-homoserine lactone (3O-C12-HSL) antagonist, a QS blocker (QSB), would interfere… CONTINUE READING

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