Modeling the coupled extracellular and intracellular environments in mammalian cell culture.

  title={Modeling the coupled extracellular and intracellular environments in mammalian cell culture.},
  author={Mukesh N. Meshram and Saeideh Naderi and Brendan J. McConkey and Brian P. Ingalls and Jeno M. Scharer and Hector M. Budman},
  journal={Metabolic engineering},
The regulation of metabolism in mammalian cell culture is closely linked to the process of apoptosis-programmed cell death. Apoptosis negatively impacts culture viability, product yield, and quality. An improved understanding of the interaction between apoptosis and metabolism will give rise to better control over the culture process, and thus improvements in product yield. This study presents a mathematical model that describes both the metabolic fluxes involving the extracellular metabolites… CONTINUE READING


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