Modeling the complex pathology of Alzheimer's disease in Drosophila.

@article{FernandezFunez2015ModelingTC,
  title={Modeling the complex pathology of Alzheimer's disease in Drosophila.},
  author={Pedro Fernandez-Funez and Lorena de Mena and Diego E Rincon-Limas},
  journal={Experimental neurology},
  year={2015},
  volume={274 Pt A},
  pages={58-71}
}
Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein (APP) processing in AD. Neurofibrillary tangles enriched in tau are the other pathological hallmark of AD, but the lack of causative tau mutations still puzzles researchers. Here… CONTINUE READING
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