Modeling the competition between aggregation and self‐assembly during virus‐like particle processing

@article{Ding2010ModelingTC,
  title={Modeling the competition between aggregation and self‐assembly during virus‐like particle processing},
  author={Yong Ding and Yap Pang Chuan and Lizhong He and Anton P. J. Middelberg},
  journal={Biotechnology and Bioengineering},
  year={2010},
  volume={107}
}
Understanding and controlling aggregation is an essential aspect in the development of pharmaceutical proteins to improve product yield, potency and quality consistency. Even a minute quantity of aggregates may be reactogenic and can render the final product unusable. Self‐assembly processing of virus‐like particles (VLPs) is an efficient method to quicken the delivery of safe and efficacious vaccines to the market at low cost. VLP production, as with the manufacture of many biotherapeutics, is… 
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