Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies.

@article{Roberts2004ModelingTC,
  title={Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies.},
  author={Reade B Roberts and Carlos L. Arteaga and David W Threadgill},
  journal={Cancer cell},
  year={2004},
  volume={5 2},
  pages={115-20}
}
Current trends foretell the use of cancer treatments customized to each patient. Genetic and molecular profiling of tumors and an increasing number of molecule-targeted therapies contribute to making this a reality. However, as targets of anticancer therapies become specific proteins or pathways, unanticipated side effects may emerge. In addition, the… CONTINUE READING