Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals

  title={Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals},
  author={Sunpeng Wang and Patricia Hottz and Mauro Schechter and Libin Rong},
  journal={PLoS computational biology},
  volume={11 12},
The progressive loss of CD4+ T cell population is the hallmark of HIV-1 infection but the mechanism underlying the slow T cell decline remains unclear. Some recent studies suggested that pyroptosis, a form of programmed cell death triggered during abortive HIV infection, is associated with the release of inflammatory cytokines, which can attract more CD4+ T cells to be infected. In this paper, we developed mathematical models to study whether this mechanism can explain the time scale of CD4+ T… CONTINUE READING
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