Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals

@article{Wang2015ModelingTS,
  title={Modeling the Slow CD4+ T Cell Decline in HIV-Infected Individuals},
  author={Sunpeng Wang and Patricia Hottz and Mauro Schechter and Libin Rong},
  journal={PLoS Computational Biology},
  year={2015},
  volume={11}
}
  • Sunpeng Wang, Patricia Hottz, +1 author Libin Rong
  • Published 2015
  • Computer Science, Medicine, Biology
  • PLoS Computational Biology
  • The progressive loss of CD4+ T cell population is the hallmark of HIV-1 infection but the mechanism underlying the slow T cell decline remains unclear. Some recent studies suggested that pyroptosis, a form of programmed cell death triggered during abortive HIV infection, is associated with the release of inflammatory cytokines, which can attract more CD4+ T cells to be infected. In this paper, we developed mathematical models to study whether this mechanism can explain the time scale of CD4+ T… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 23 CITATIONS

    An HIV model with age-structured latently infected cells

    VIEW 1 EXCERPT
    CITES BACKGROUND

    FILTER CITATIONS BY YEAR

    2016
    2020

    CITATION STATISTICS

    • 1 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 90 REFERENCES

    Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy.

    VIEW 1 EXCERPT

    In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4+ but not CD8+ T cells depleted?

    VIEW 1 EXCERPT