Modeling the Potential Impact of Host Population Survival on the Evolution of M. tuberculosis Latency

@inproceedings{Zheng2014ModelingTP,
  title={Modeling the Potential Impact of Host Population Survival on the Evolution of M. tuberculosis Latency},
  author={Nibiao Zheng and Christopher C Whalen and Andreas Handel},
  booktitle={PloS one},
  year={2014}
}
Tuberculosis (TB) is an infectious disease with a peculiar feature: Upon infection with the causative agent, Mycobacterium Tuberculosis (MTB), most hosts enter a latent state during which no transmission of MTB to new hosts occurs. Only a fraction of latently infected hosts develop TB disease and can potentially infect new hosts. At first glance, this seems like a waste of transmission potential and therefore an evolutionary suboptimal strategy for MTB. It might be that the human immune… CONTINUE READING
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