Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation

@article{Wilkie2017ModelingTD,
  title={Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation},
  author={Kathleen Wilkie and P. Hahnfeldt},
  journal={Bulletin of Mathematical Biology},
  year={2017},
  volume={79},
  pages={1426-1448}
}
  • Kathleen Wilkie, P. Hahnfeldt
  • Published 2017
  • Biology, Medicine, Mathematics
  • Bulletin of Mathematical Biology
  • Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor development, cancer dormancy, and immunotherapies. In fact, early immunotherapy failures were partly due to a lack in understanding of the nonlinear growth dynamics these competing immune actions may cause. To study this biological phenomenon theoretically, we… CONTINUE READING
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