Modeling the Cell Cycle: Why Do Certain Circuits Oscillate?

@article{Ferrell2011ModelingTC,
  title={Modeling the Cell Cycle: Why Do Certain Circuits Oscillate?},
  author={James E Ferrell and Tony Yu-Chen Tsai and Qiong Yang},
  journal={Cell},
  year={2011},
  volume={144},
  pages={874-885}
}
Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic cell cycle operate like autonomous oscillators. Here, we present the basic theory of oscillatory biochemical circuits in the context of the Xenopus embryonic cell cycle. We examine… CONTINUE READING
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