Modeling the Amplification Dynamics of Human Alu Retrotransposons

@article{Hedges2005ModelingTA,
  title={Modeling the Amplification Dynamics of Human Alu Retrotransposons},
  author={Dale J. Hedges and Richard Cordaux and Jinchuan Xing and David J. Witherspoon and Alan R. Rogers and Lynn B. Jorde and Mark A. Batzer},
  journal={PLoS Computational Biology},
  year={2005},
  volume={1},
  pages={860 - 921}
}
Retrotransposons have had a considerable impact on the overall architecture of the human genome. Currently, there are three lineages of retrotransposons (Alu, L1, and SVA) that are believed to be actively replicating in humans. While estimates of their copy number, sequence diversity, and levels of insertion polymorphism can readily be obtained from existing genomic sequence data and population sampling, a detailed understanding of the temporal pattern of retrotransposon amplification remains… CONTINUE READING

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