Modeling the 3D structure of GPCRs from sequence.

  title={Modeling the 3D structure of GPCRs from sequence.},
  author={Sharon Shacham and Maya Topf and Noa Avisar and Fabian Glaser and Yael Marantz and Shay Bar-Haim and Silvia Noiman and Zvi Naor and Oren M. Becker},
  journal={Medicinal research reviews},
  volume={21 5},
G-protein-coupled receptors (GPCRs) are a large and functionally diverse protein superfamily, which form a seven transmembrane (TM) helices bundle with alternating extra-cellular and intracellular loops. GPCRs are considered to be one of the most important groups of drug targets because they are involved in a broad range of body functions and processes and are related to major diseases. In this paper we present a new technology, named PREDICT, for modeling the 3D structure of any GPCR from its… CONTINUE READING