Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages w

@inproceedings{Fang2011ModelingSD,
  title={Modeling synergistic drug inhibition of Mycobacterium tuberculosis growth in murine macrophages w},
  author={Xin Fang and Anders Wallqvist and Jaques Reifman},
  year={2011}
}
We developed a metabolism-based systems biology framework to model drug-induced growth inhibition of Mycobacterium tuberculosis in murine macrophage cells. We used it to simulate ex vivo bacterial growth inhibition due to 3-nitropropionate (3-NP) and calculated the corresponding timeand drug concentration-dependent dose-response curves. 3-NP targets the… CONTINUE READING