Modeling study of mecamylamine block of muscle type acetylcholine receptors

@article{Ostroumov2007ModelingSO,
  title={Modeling study of mecamylamine block of muscle type acetylcholine receptors},
  author={Konstantin Ostroumov and A. R. Shaikhutdinova and Andrey Skorinkin},
  journal={European Biophysics Journal},
  year={2007},
  volume={37},
  pages={393-402}
}
The blocking action of mecamylamine on different types of nicotinic acetylcholine receptors (nAChRs) has been extensively studied and used as a tool to characterize the nAChRs from different synapses. However, mechanism of mecamylamine action was not fully explored for all types of nAChRs. In the present study, we provide brief description of the mecamylamine action on muscle nAChRs expressed at the frog neuromuscular junction. In this preparation mecamylamine block of nAChRs was accompanied by… CONTINUE READING